Pathological Changes in the Liver Parenchyma of Reptiles as a Factor Influencing the Processes of Hematopoiesis (on the Example of Lacertidae: Eremias arguta)
Abstract
The influence of liver repair processes on haematopoiesis in scaly reptiles, in particular the steppe runner Eremias arguta (Pallas, 1773) is considered. Specimens with maximum and minimum liver parenchyma damage were selected from the same biotope and their liver myelogram indices were compared. It was shown that macrophage activation during liver repair stimulates lymphoid and myeloid haematopoietic progenitor cells in steppe runners. On the contrary, differentiation of erythroid cells at the normocyte stage is somewhat reduced, probably due to lack of resources.References
Alibardi, L. 2014. Histochemical, biochemical and cell biological aspects of tail regeneration in lizard, an amniote model for studies on tissue regeneration. Progress in Histochemistry and Cytochemistry, 48 (4), 143-244.
https://doi.org/10.1016/j.proghi.2013.12.001
Alibardi, L. 2017. Hyaluronic acid in the tail and limb of amphibians and lizards recreates permissive embryonic conditions for regeneration due to its hygroscopic and immunosuppressive properties. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 328 (8), 760-771.
https://doi.org/10.1002/jez.b.22771
Akulenko, N. M. 2012. Haemopoietic system of the anurans: the role of bone marrow and liver. Vestnik zoologii, 46 (4), 347-354.
https://doi.org/10.2478/v10058-012-0027-8
Akulenko, N. M. 2015. Changes in liver parenchyma of green frogs (Pelophylax esculentus complex) under conditions of anthropogenic pollution and their use in monitoring water bodies. Vestnik Zoologii, 49 (5), 453-458.
https://doi.org/10.1515/vzoo-2015-0053
Akulenko, N. M. 2021. Liver pigment cells of the green frog (Pelophylax esculentus complex) are involved in hematopoiesis and liver parenchyma repair. International Journal of Scientific Research, 10 (10), 83-84.
https://doi.org/10.36106/ijsr/8731395
Bingqiang, H., Honghua, S. & Yongjun, W. 2021. Self-Control of Inflammation during Tail Regeneration of Lizards. Journal of Developmental Biology, 9 (4), 48.
https://doi.org/10.3390/jdb9040048
de Carvalho, M. P. N., Queiroz-Hazarbassanov, N. G. T., de Oliveira Massoco, Cr., Sant'Anna, S. St., Lourenzo, M. M., Levin, G., Sogayar, K., Fernandes Grego, M. C. & Catгo-Dias, J. L. 2017. Functional characterization of neotropical snakes peripheral blood leukocytes subsets: Linking flow cytometry cell features, microscopy images and serum corticosterone levels. Developmental and Comparative Immunology ,74, 144-153.
https://doi.org/10.1016/j.dci.2017.04.007
Grayfer, L.& Robert, J. 2016. Amphibian macrophage development and antiviral defenses. Developmental and Comparative Immunology, 58, 60-67.
https://doi.org/10.1016/j.dci.2015.12.008
Koibuchi, N., Kaneda, Y., Taniyama, Y., Matsumoto, K., Nakamura, T., Ogihara, T. & Morishita, R. 2004. Essential role of HGF (hepatocyte growth factor) in blood formation in Xenopus. Blood, 103 (9), 3320-3325.
https://doi.org/10.1182/blood-2003-02-0352
Mescher, A. L., Neff, A. W. & Kingac, M. W. 2017. Inflammation and immunity in organ regeneration. Developmental and Comparative Immunology, 66, 98-110.
https://doi.org/10.1016/j.dci.2016.02.015
Mescher, A. L. & Neff, A. W. 2005. Regenerative capacity and the developing immune system. Advances in Biochemical Engineering / Biotechnology, 93, 39-66.
https://doi.org/10.1007/b99966
Paredes, L. C., Saraiva Camara, N. O. & Braga, T. T. 2019. Understanding the Metabolic Profile of Macrophages During the Regenerative Process in Zebrafish. Frontiers in Physiology, 10, 61.
https://doi.org/10.3389/fphys.2019.00617
Stacy, N. I, Alleman, A .R. & Sayler, K. A. 2011. Diagnostic hematology of reptiles. Clinics in Laboratory Medicine, 31 (1), 87-108.
https://doi.org/10.1016/j.cll.2010.10.006
Vonk, A. C., Zhao, X., Pan, Z., Hudnall, M. L., Oakes, C. G., Lopez, G. A., Hasel-Kolossa, S. C., Kuncz, A. W. C., Sengelmann, S. B., Gamble, D. J. & Lozito, T. P. 2023 Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis. Nature Communications, 14 (1), 4489.
https://doi.org/10.1038/s41467-023-40206-z
Yaparla, A., Wendel, E., Grayfer, L., 2016. The unique myelopoiesis strategy of the amphibian Xenopus laevis. Developmental and Comparative Immunology.
